Differential associations between retinal signs and CMBs by location: The AGES-Reykjavik Study

Neuro Imaging Researc

Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci

Refractive error (RE) is a complex, multifactorial disorder characterized by a mismatch between the optical power of the eye and its axial length that causes object images to be focused off the retina. The two major subtypes of RE are myopia (nearsightedness) and hyperopia (farsightedness), which represent opposite ends of the distribution of the quantitative measure of spherical refraction. We performed a fixed effects meta-analysis of genome-wide association results of myopia and hyperopia from 9 studies of European-derived populations: AREDS, KORA, FES, OGP-Talana, MESA, RSI, RSII, RSIII and ERF. One genome-wide significant region was observed for myopia, corresponding to a previously identified myopia locus on 8q12 (p = 1.25610-8), which has been reported by Kiefer et al. as significantly associated with myopia age at onset and Verhoeven et al. as significantly associated to mean spherical-equivalent (MSE) refractive error. We observed two genomewide significant association

Emphysema, airflow limitation, and early age-related macular degeneration

10.1001/archophthalmol.2010.25Archives of Ophthalmology1284472-477AROP

Retinal vascular caliber and brachial flow-mediated dilation: The multi-ethnic study of atherosclerosis

10.1161/STROKEAHA.110.581017Stroke4171343-134

Retinal vascular caliber, cardiovascular risk factors, and inflammation: The Multi-Ethnic Study of Atherosclerosis (MESA)

10.1167/iovs.05-1539Investigative Ophthalmology and Visual Science4762341-2350IOVS

Traditional and novel cardiovascular risk factors for retinal vein occlusion: The multiethnic study of atherosclerosis

10.1167/iovs.08-1826Investigative Ophthalmology and Visual Science49104297-4302IOVS

Diabetic Retinopathy in a Multi-ethnic Cohort in the United States

10.1016/j.ajo.2005.08.063American Journal of Ophthalmology141

Ten-year longitudinal changes in retinal microvascular lesions: The atherosclerosis risk in communities study

10.1016/j.ophtha.2011.01.003Ophthalmology11881612-1618OPHT